Custom Synthesis

Synthetic Projects and Drug Design

What We Do?

ADKL Labs provide insights beyond the analytical perspective. Through their years of experience in drug design, synthetic organic synthesis, medicinal chemistry, analytical techniques and instrumentation, ADKL Labs offer expertise on a variety of platforms, pathways and strategies.

The team at ADKL Labs have many years experience within the medicinal chemistry industry, specifically in the area of lead design and synthesis (structure and fragment-based). Our team is committed to applying our experience to solving the synthetic chemistry needs of our clients. We welcome the opportunity to investigate or improve existing synthetic pathways as well as guide the development of new synthetic pathways. With many years of experience in the field, our team is well placed to offer insights and assist in the production of synthetic targets.

Organic syntheses require purity analysis, impurity analysis and structural elucidation for accurate and reliable characterisation of target compounds. Working within the industry has enabled the ADKL Labs team to build an expertise within the area of structural elucidation through the use of various spectrometric and spectroscopic instrumentation and techniques. Over the years our team has developed expertise in the synthesis, isolation and characterisation of a multitude of synthetic targets and chemical classes. Therefore, our team is uniquely positioned to offer synthetic chemistry services in tandem with structural elucidation, characterisation and purity/impurity analysis.

We offer:

Drug design and custom synthesis

Guide design of target compounds.

Relate targets to synthetic practicality.

Retrosynthetic impurity analysis and characterisation

Complimentary analytical techniques for complete characterisation

Chromatography (LC & GC), Mass Spectrometry, NMR and IR

Specialised organic synthesis (development, pilot and scale-up)

Small scale investigative synthetic targets

Multi-step synthetic pathways

Development of synthetic scale-up programs

Method development (HPLC, LCMSD, GC, GCMSD)

Guide development of conditions, detector optimisation and processing

Compound (unknown) identification

Chromatographic isolation and purification

Purification

Structural elucidation

Synthetic pathway optimisation and consulting

Iterative optimisation

Workflow analysis and troubleshooting

Support to ensure a project

Over the years our ADKL Labs team have accumulated a wealth of knowledge, across a range of critical disciplines. With many years of experience in the below fields the ADKL Labs team is able to guide and support successful startup formation through an incubator environment. Having access to multiple services located on site enables a focused, centralised startup to minimise outsourcing while maximising resources.

Our team can guide the implementation and successful adoption of strategies in:

Precise and careful consideration of occupational health and safety requirements, storage and disposal of chemicals/waste

Training in the handling of reagents, instruments and equipment

Synthetic workflows and setup protocols

Purification strategies - ranging from re-crystallization, extractions, solid phase extraction, flash chromatography, automated flash chromatography/fraction collection, mass-triggered fraction collection and more

Identification of intermediate, final and degradation products - the range of techniques available on site include HPLC, GC, LCMS, GCMS and more

Characterisation of target compounds and impurities - interpretation of complex data requires experience and expertise to understand effectively